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. 2021 Mar 5;19:98. doi: 10.1186/s12967-021-02770-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — CpG islands methylation of the HPSE2 promoter. a Heat map of 49 methylated CpG islands located in the promoter region of HPSE2 from TCGA database; b Pearson correlation of methylation sites and HPSE2 expression with cor < − 0.3 were selected; c Differentially methylated CpG islands between normal and tumor tissues from TCGA database; d Differentially methylated CpG islands of the HPSE2 promoter among adenocarcinoma, adenoma, and normal tissues from the GSE68484 dataset. ***P < 0.001