Table 5.
Drug resistance-conferring allele’s frequency across the 5 P. falciparum populations
| Genes | Chromosome | Position | Mutation site | Ethiopia | Cambodia | DR Congo | Malawi | Thailand |
|---|---|---|---|---|---|---|---|---|
| DHFR | 4 | 748,577 | I164L | 0 | 0.5 | 0 | 0 | 0.84 |
| DHFR | 4 | 748,410 | S108N | 0 | 1 | 1 | 1 | 1 |
| DHFR | 4 | 748,262 | C59R | 0.86 | 1 | 0.86 | 0.99 | 1 |
| DHFR | 4 | 748,239 | N51I | 1 | 0.95 | 1 | 1 | 0.95 |
| MDR1 | 5 | 961,625 | D1246Y | 0 | 0 | 0.17 | 0 | 0 |
| MDR1 | 5 | 958,145 | N86Y | 0.14 | 0 | 0.48 | 0.03 | 0 |
| MDR1 | 5 | 961,566 | F1226Y | 0 | 0.04 | 0 | 0 | 0.59 |
| MDR1 | 5 | 958,440 | Y184F | 1 | 0.58 | 0.32 | 0.35 | 0.06 |
| CRT | 7 | 405,600 | I356T | 0 | 0.52 | 0.27 | 0 | 1 |
| CRT | 7 | 405,362 | N326S | 0.98 | 0.51 | 0 | 0 | 1 |
| CRT | 7 | 405,838 | R371I | 0 | 0.8 | 0.71 | 0 | 1 |
| CRT | 7 | 404,407 | A220S | 1 | 1 | 0.663 | 0 | 1 |
| CRT | 7 | 403,625 | K76T | 1 | 1 | 0.66 | 0 | 1 |
| CRT | 7 | 404,836 | Q271E | 1 | 1 | 0.7143 | 0 | 1 |
| DHPS | 8 | 549,685 | G437A | 0.08 | 0.13 | 0.08 | 0.01 | 0 |
| DHPS | 8 | 549,995 | K540N | 0 | 0.4 | 0 | 0 | 0.03 |
| DHPS | 8 | 549,681 | S436A | 0 | 0.2 | 0.11 | 0.02 | 0.17 |
| DHPS | 8 | 550,117 | A581G | 0.02 | 0.4 | 0.03 | 0.02 | 0.82 |
| K13 | 13 | 1,726,432 | K189T | 0.2 | 0 | 0.17 | 0.13 | 0 |
| K13 | 13 | 1,725,259 | C580Y | 0 | 0.36 | 0 | 0 | 0.26 |