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. 2021 Mar 4;23:29. doi: 10.1186/s13058-021-01406-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The combination of ALRN-6924 and chemotherapeutic agents synergistically inhibit cell proliferation in vitro. a Cells were seeded in 96-well plates at a density of 5000–10,000 cells per well then treated for 72 h with vehicle, ALRN-6924, paclitaxel, eribulin, or combination of each. Effect on cell growth was determined using the SRB assay. IC₅₀ values were calculated using GraphPad Prism software. b Combination indices were calculated using the Chou-Talalay method with a CI < 1 indicating synergistic activity. c MCF-7 colony formation assay treated for 14 days with either vehicle, ALRN-6924, paclitaxel, or combination of ALRN-6924 and paclitaxel. Total colony area was measured by using NIH ImageJ software. Mean ± SD (n = 2) values are shown