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. 2021 Mar 4;9:17. doi: 10.1186/s40364-021-00270-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Positive correlation between BCL11B and PTK7 in T-cell acute lymphoblastic leukemia (T-ALL). (a) The expression levels of BCL11B (left panel) and PTK7 (right panel) in T-ALL patients and healthy individuals (HIs) in the GSE13159 dataset. (b) Validation of the correlation between BCL11B and PTK7. Expression levels of the PTK7 gene in PBMCs from T-ALL patients and His (left panel). Linear correlation analysis of the BCL11B and PTK7 genes in T-ALL samples (right panel). (c) BCL11B and PTK7 are positively correlated in the GSE13159 dataset. Left panel: co-expression modules were obtained by weighted gene co-expression network analysis (WGCNA). The colored row beneath the dendrogram shows the module assignment determined by the Dynamic Tree Cut. A cluster dendrogram demonstrated that 10,459 differentially expressed genes were enriched in 11 co-expression network modules, while BCL11B and PTK7 were located in the same blue module. Right panel: a positive correlation was detected between BCL11B and PTK7. Both BCL11B (d) and PTK7 (e) are highly expressed in T-ALL compared to lymphoma cell lines. Data were obtained through the Cancer Cell Line Encyclopedia (CCLE). Detailed methods are available in Materials and Methods in Additional file 1