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. 2021 Mar 5;21:80. doi: 10.1186/s12890-021-01439-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Adventitial fibroblasts senescence is observed in the MCT-induced PH rat model. a. Representative images of H&E staining, SA-β-gal staining and Fibronectin-IHC with SA-β-gal staining of rat lung tissues in MCT and control groups. b RV/(LV+S) was determined in each group (n = 8 rats per group). c The quantification of SA-β-gal positive cells normalized to the Con group in Fig. 1a (three pulmonary arteries per rat). d, e. Fold change by qRT-PCR: relative mRNA level of p16/β-actin and p19/β-actin in lung tissues of MCT rats to that in control rats (n = 3 rats per group). All data are shown as the mean ± SEM. Statistical significance compared to controls was assessed using the unpaired two-tailed Student’s t test: ***P < 0.001, ****P < 0.0001