Fig. 5.

Reduction in the EOG and numbers of mature OSNs in APP/PS1 OE. a Diagram showing EOG recording in the olfactory turbinate. b Representative EOG traces from olfactory turbinate of WT and APP/PS1 mice in response to odor (amyl acetate) application. c Significantly decreased EOG amplitude (p = 3 × 10^− 5), increased rise time (p = 0.008) and unchanged decay time of EOG (p = 0.583) (n = 7, per genotype). d-e Immunofluorescent staining of OMP and quantification showing marked reduction in numbers of mature OSNs in the APP/PS1 OE (n = 5 slices from 3 mice, per genotype, p = 0.005). Scale bar: 20 μm. Values represent mean ± SEM. Two-sample t-test. **p < 0.01; ***p < 0.001