Fig. 8.

Reducing interstitial fluid levels of Aβ reverses the abnormalities of gamma power in APP/PS1 OB. a Representative images of Aβ deposition in the OB of APP/PS1 mice aged 3–5 and 14–15 months, suggesting a lack of obvious amyloid plaques in 3–5 month-old APP/PS1 OB. Scale bar: 50 μm. b-c Two-day IP injection of LY-411575 significantly decreased gamma power (n = 11 for vehicle-treated WT and 12 for LY-411575-treated WT, n = 9 for vehicle-treated APP/PS1 and 12 for LY-411575-treated APP/PS1; p = 0.006 for WT + vehicle vs APP/PS1 + vehicle; p = 0.001 for APP/PS1 + vehicle vs APP/PS1 + LY-411575, two-way ANOVA with Bonferroni’s post-hoc test). d Increased levels of CTFs specifically in APP/PS1 OB confirming the effect of LY-411575 in reducing Aβ production. Values represent mean ± SEM. **p < 0.01