Fig. 4.

Functional analysis of differentially variable (DV) genes. a, b The mean expression is correlated with the Gaussian fraction of the mixture model fit and reversely correlated with the trimmed CV. Each dot represents one gene. Genes are color-coded based on the Gaussian component in the mixture model fit where orange represents pure Gaussian distribution and black represents no Gaussian fraction. The CV is transformed in a layered fashion (green ellipses) into the variability ranked score (b) which is independent of the mean. c Shown is the variability rank score of all genes in the 180Q mutant vs WT cells. Genes which are known to interact with the HTT protein and are significantly differentially variable are marked in red