Table 2.
Univariate and multivariate Cox analysis for BC patients with BM in surgery group
| Univariate Cox analysis | Multivariate Cox analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| HR | 95%CI | P | HR | 95%CI | P | |||
| Age | ||||||||
| < 51 | 1 | 1 | ||||||
| 51–78 | 1.344 | 1.087 | 1.662 | 0.006 | 1.320 | 1.054 | 1.653 | 0.016 |
| > 78 | 3.250 | 2.367 | 4.463 | 0.000 | 3.038 | 2.129 | 4.336 | 0.000 |
| Race | ||||||||
| Black | 1 | 1 | ||||||
| Other | 0.643 | 0.421 | 0.982 | 0.041 | 0.642 | 0.417 | 0.990 | 0.045 |
| White | 0.682 | 0.537 | 0.866 | 0.002 | 0.712 | 0.554 | 0.915 | 0.008 |
| Sex | ||||||||
| Female | 1 | |||||||
| Male | 1.486 | 0.838 | 2.637 | 0.176 | ||||
| Primary site | ||||||||
| Central portion | 1 | |||||||
| Upper-inner | 0.998 | 0.661 | 1.506 | 0.993 | ||||
| Lower-inner | 1.271 | 0.794 | 2.034 | 0.317 | ||||
| Upper-outer | 1.121 | 0.810 | 1.552 | 0.492 | ||||
| Lower-outer | 0.877 | 0.562 | 1.366 | 0.561 | ||||
| Others | 1.025 | 0.737 | 1.425 | 0.885 | ||||
| Laterality | ||||||||
| Left | 1 | |||||||
| Right | 0.908 | 0.759 | 1.086 | 0.290 | ||||
| Histological type | ||||||||
| Ductal | 1 | 1 | ||||||
| Lobular | 1.048 | 0.838 | 1.311 | 0.681 | 1.083 | 0.845 | 1.387 | 0.528 |
| Others | 1.774 | 1.164 | 2.705 | 0.008 | 1.891 | 1.231 | 2.905 | 0.004 |
| Grade | ||||||||
| I | 1 | 1 | ||||||
| II | 1.187 | 0.800 | 1.762 | 0.395 | 1.307 | 0.874 | 1.955 | 0.192 |
| III | 1.959 | 1.337 | 2.871 | 0.001 | 1.968 | 1.313 | 2.952 | 0.001 |
| IV | 8.574 | 2.036 | 36.105 | 0.003 | 4.009 | 0.909 | 17.675 | 0.067 |
| T stage | ||||||||
| T1 | 1 | |||||||
| T2 | 1.750 | 1.217 | 2.516 | 0.003 | ||||
| T3 | 2.355 | 1.612 | 3.439 | 0.000 | ||||
| T4 | 2.163 | 1.477 | 3.168 | 0.000 | ||||
| N stage | ||||||||
| N0 + N1 | 1 | 1 | ||||||
| N2 + N3 | 1.358 | 1.136 | 1.623 | 0.001 | 1.221 | 1.010 | 1.477 | 0.039 |
| Surgery | ||||||||
| BCS | 1 | 1 | ||||||
| Mastectomy | 1.466 | 1.201 | 1.789 | 0.000 | 1.253 | 1.007 | 1.558 | 0.043 |
| Radiotherapy | ||||||||
| No | 1 | |||||||
| Yes | 0.813 | 0.680 | 0.972 | 0.023 | ||||
| Chemotherapy | ||||||||
| No | 1 | 1 | ||||||
| Yes | 0.774 | 0.646 | 0.929 | 0.006 | 0.729 | 0.585 | 0.909 | 0.005 |
| Brain metastasis | ||||||||
| No | 1 | 1 | ||||||
| Yes | 2.177 | 1.359 | 3.488 | 0.001 | 2.694 | 1.656 | 4.382 | 0.000 |
| Liver metastasis | ||||||||
| No | 1 | 1 | ||||||
| Yes | 1.993 | 1.585 | 2.506 | 0.000 | 2.207 | 1.725 | 2.824 | 0.000 |
| Lung metastasis | ||||||||
| No | 1 | |||||||
| Yes | 1.647 | 1.314 | 2.066 | 0.000 | 1.274 | 1.003 | 1.619 | 0.047 |
| Tumor size, cm | ||||||||
| < 2 | 1 | 1 | ||||||
| 2–5 | 1.665 | 1.145 | 2.420 | 0.008 | 1.370 | 0.938 | 2.003 | 0.104 |
| > 5 | 2.504 | 1.716 | 3.653 | 0.000 | 1.818 | 1.223 | 2.703 | 0.003 |
| Breast subtype | ||||||||
| HR−/HER2+ | 1 | 1 | ||||||
| HR+/HER2- | 1.414 | 0.899 | 2.223 | 0.134 | 1.770 | 1.097 | 2.854 | 0.019 |
| HR+/HER2+ | 1.052 | 0.634 | 1.746 | 0.845 | 1.160 | 0.691 | 1.946 | 0.574 |
| HR−/HER2- | 3.584 | 2.203 | 5.832 | 0.000 | 3.603 | 2.185 | 5.943 | 0.000 |
| Insurance status | ||||||||
| Uninsured | 1 | |||||||
| Insured | 0.621 | 0.365 | 1.057 | 0.079 | ||||
| Marital status | ||||||||
| Unmarried | 1 | |||||||
| Married | 0.743 | 0.622 | 0.888 | 0.001 | ||||
BC breast cancer, BM bone metastases,