Table 3.

Univariate and multivariate Cox analysis for BC patients with BM in non-surgery group

	Univariate Cox analysis				Multivariate Cox analysis
	HR	95%CI		P	HR	95%CI		P
Age
< 51	1				1
51–78	1.421	1.219	1.657	0.000	1.425	1.218	1.667	0.000
> 78	2.247	1.827	2.764	0.000	2.300	1.839	2.875	0.000
Race
Black	1				1
Other	0.732	0.558	0.960	0.024	0.803	0.609	1.059	0.120
White	0.807	0.687	0.948	0.009	0.795	0.673	0.939	0.007
Sex
Female	1
Male	1.139	0.659	1.968	0.641
Primary site
Central portion	1
Upper-inner	1.118	0.840	1.487	0.444
Lower-inner	1.237	0.910	1.681	0.174
Upper-outer	1.006	0.804	1.259	0.957
Lower-outer	1.004	0.738	1.367	0.978
Others	1.122	0.894	1.408	0.322
Laterality
Left	1
Right	1.034	0.916	1.168	0.584
Histological type
Ductal	1				1
Lobular	1.043	0.881	1.236	0.622	1.239	1.038	1.479	0.018
Others	1.651	1.292	2.109	0.000	1.450	1.131	1.859	0.003
Grade
I	1				1
II	1.177	0.946	1.464	0.144	1.289	1.032	1.610	0.025
III	1.662	1.332	2.073	0.000	1.634	1.291	2.067	0.000
IV	2.917	1.354	6.287	0.006	2.295	1.049	5.021	0.037
T stage
T1	1
T2	0.880	0.732	1.058	0.174
T3	0.928	0.753	1.145	0.487
T4	1.043	0.861	1.262	0.667
N stage
N0 + N1	1
N2 + N3	1.097	0.936	1.286	0.254
Radiotherapy
No	1
Yes	1.116	0.986	1.264	0.084
Chemotherapy
No	1				1
Yes	0.855	0.757	0.966	0.012	0.710	0.613	0.823	0.000
Brain metastasis
No	1				1
Yes	2.113	1.715	2.604	0.000	1.763	1.418	2.192	0.000
Liver metastasis
No					1
Yes	1.569	1.373	1.793	0.000	1.601	1.378	1.859	0.000
Lung metastasis
No					1
Yes	1.403	1.231	1.601	0.000	1.232	1.074	1.413	0.003
Tumor size, cm
< 2	1
2–5	0.934	0.781	1.116	0.450
> 5	1.016	0.841	1.228	0.867
Breast subtype
HR−/HER2+	1				1
HR+/HER2-	0.827	0.635	1.076	0.157	0.872	0.656	1.160	0.348
HR+/HER2+	0.726	0.538	0.981	0.037	0.713	0.527	0.966	0.029
HR−/HER2-	3.412	2.500	4.657	0.000	3.320	2.419	4.557	0.000
Insurance status
Uninsured	1
Insured	1.002	0.758	1.324	0.990
Marital status
Unmarried	1				1
Married	0.770	0.681	0.872	0.000	0.850	0.748	0.965	0.012

BC breast cancer, BM bone metastases