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. 2021 Mar 4;12:163. doi: 10.1186/s13287-021-02234-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Decreased H3K9ac level of TGFβRI mediated the poor chondrogenic differentiation of WJ-MSCs. a RT-qPCR analysis of TGFβRI, Smad2, and Smad3 after chondrogenic differentiation in the control and IUGR groups. b RT-qPCR analysis of TGFβRI, Smad2, and Smad3 after chondrogenic differentiation in the 300, 600, and 1200 nM cortisol groups. n = 5. c, e ChIP-PCR analysis of H3K9ac and H3K27ac levels of TGFβRI, Smad2, and Smad3, COL2A1 and ACAN after chondrogenic differentiation in the control and IUGR groups. n = 3. d, f ChIP-PCR analysis of H3K9ac and H3K27ac of TGFβRI, Smad2, and Smad3, COL2A1 and ACAN after chondrogenic differentiation in the 300, 600, and 1200 nM cortisol groups. n = 3. H3K9ac, histone 3 lysine 9 acetylation; H3K27ac, histone 3 lysine 27 acetylation; RT-qPCR, real-time quantitative polymerase chain reaction; TGFβRI, transforming growth factor β receptor I; COL2A1, α1 chain of type II collagen; ACAN, aggrecan; WJ-MSCs, Wharton’s jelly-derived mesenchymal stem cells; IUGR, intrauterine growth retardation; ChIP-PCR, chromatin immunoprecipitation-polymerase chain reaction. Data are Mean ± S.E.M. **P < 0.01 vs control