Table 3.
NanoString counts of individual genes of significance (p values < 0.05), analyzed from tumor core biopsy samples prior to study treatment. Fold change is PR vs PD (baseline)
| Gene name | PR | PD | Fold change | Affected pathway |
|---|---|---|---|---|
| CALML5 | 143.27 | 2255.68 | − 15.74 | MAPK |
| MMP7 | 453.82 | 5649.84 | − 12.45 | WNT |
| BRCA1 | 57.16 | 275.57 | − 4.82 | DNA damage repair, PI3K |
| PLA2G3 | 196.18 | 41.35 | 4.74 | MAPK |
| CRYAB | 568.51 | 2587.04 | − 4.55 | DNA damage repair |
| COL11A1 | 65.8 | 294.98 | − 4.48 | PI3K |
| CKB | 100.47 | 438.12 | − 4.36 | DNA |
| LFNG | 722.24 | 175.07 | 4.13 | Notch |
| RASGRF1 | 41.19 | 156.18 | − 3.79 | MAPK |
| PIK3R3 | 2009.36 | 558.36 | 3.6 | JAK/STAT, MAPK, PI3K |
| SOCS1 | 362.96 | 104.85 | 3.46 | JAK/STAT |
| GJB2 | 395.9 | 125.75 | 3.15 | DNA damage repair |
| PTCH1 | 23.77 | 72.6 | − 3.05 | Hedgehog |
| STAT1 | 5748.18 | 1940.41 | 2.96 | JAK/STAT |
| COL27A1 | 81.66 | 209.94 | − 2.57 | PI3K |
| SOCS2 | 498.48 | 197 | 2.53 | JAK/STAT |
| FGFR2 | 133.74 | 333.34 | − 2.49 | MAPK, PI3K |
| NOTCH1 | 194.05 | 439.53 | − 2.27 | Notch |
| HGF | 181.46 | 81.94 | 2.21 | MAPK, PI3K |