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. 2020 Oct 31;29(3):1120–1137. doi: 10.1016/j.ymthe.2020.10.024

Figure 1.

Figure 1

lncRNA Gm15834 Was the High-Risk Factor of Cardiac Hypertrophy and Was Regulated by NF-κB

(A) The pipelines of identification of cardiac hypertrophy associated high-risk lncRNAs based on bioinformatics analysis. (B) The heatmaps of differentially expressed lncRNAs that identified from cardiac hypertrophy-related RNA-seq (left) and microarray (right) datasets. The common lncRNAs were highlighted in red. (C) The visualization of the lncRNA-mRNA coexpression network. lncRNA names were labeled in purple, and disease seed genes were labeled in blue. (D) The expression heatmap of lncRNA Gm15834 in multiple tissues. Rectangles represented the high-expressed tissues, rows represented data sources (Fantom5 project), and columns represented tissues. (E) UCSC genome browser tracks of lncRNA Gm15834 gene epigenomics signals in heart tissues. (F) The dynamic expression of lncRNA Gm15834 in different stages of heart development. (G) The effect of NF-κB on lncRNA Gm15834 promoter dual-luciferase activity. ∗p < 0.05 versus Gm15834-WT group; #p < 0.05 versus NF-κB + Gm15834-MUT group. n = 3.