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. 2020 Dec 3;29(3):1335–1348. doi: 10.1016/j.ymthe.2020.11.031

Figure 1.

Figure 1

IFN-α Inhibited the Expression of MAVS in HepG2.2.15 Cells

(A) Twenty candidate genes for differential expression analysis and potential RNA editing screening of ADAR1 via sequence analysis of transcription group. (B) qPCR analysis of mRNA levels of ADAR1 and MAVS at different concentrations of IFN-α. (C) Western blot analysis of ADAR1 P150 and MAVS protein expression at different concentrations of IFN-α normalized to GAPDH. Right panel shows quantification from three replicates. (D) Western blot analysis and quantification of protein levels of ADAR1 and MAVS in ADAR1 overexpressing HepG2.2.15 cells at different concentrations of IFN-α. Data represent the mean ± SD of three independent experiments. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.