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. 2020 Nov 20;29(3):1226–1238. doi: 10.1016/j.ymthe.2020.11.024

Figure 6.

Figure 6

M2 Macrophage-Derived Exosomal miR-155-5p and miR-221-5p Promote Angiogenesis and Growth of PDAC In Vivo

(A) Weight of tumors in each group. (B) The tumor growth curve shows the tumor size measured every 3 days. (C) Representative IHC graph staining for CD31 in tumor tissue of nude mice. Scale bars, 100 μm. (D) Dot plot shows the MVD in tumor tissue of nude mice by CD31. (E) Schematic model of M2 MDE promoting PDAC angiogenesis and growth by exosomal miR-155-5p and miR-221-5p by targeting E2F2. ∗p < 0.05, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.