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. 2020 Nov 20;29(3):1001–1015. doi: 10.1016/j.ymthe.2020.11.023

Figure 6.

Figure 6

Gene Transcriptome Patterns of the Immune System Process in the Gene-Corrected HT1 Rabbits

(A and B) Hierarchical cluster analysis (A) and principal-component analysis (B) of the wild-type rabbits (n = 3), AAV-treated HT1 rabbits (n = 3), and PBS-treated HT1 rabbits (n = 3) using immune system process gene (n = 1,300). (C) Number of differentially expressed genes between AAV-treated HT1 rabbits and wild-type rabbits. There are 28 common differentially expressed genes of the immune system process. (D) Heatmap of the 28 common differentially expressed genes in the immune system process in (C). (E) Expression levels of the genes that have been reported to be involved in host immune responses to AAV.