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Solvent screening results for the SMA of naphthalene-1-thiol to chalcone derivative 11c.
 | ||||
| Entrya | Solvent | Time (h) | Yieldb (%) | eec (%) |
| 1 | THF | 20 | >99 | 23 |
| 2 | toluene | 6 | 95 | 78 |
| 3 | dioxane | 20 | 78 | 76 |
| 4 | DCM | 6 | 94 | 93 |
aUnless stated otherwise, all reactions were performed with 0.20 mmol 11c and 0.40 mmol naphthalene-1-thiol in 1.0 mL of solvent, in the presence of 1 mol % 5 at rt. bIsolated yields. cDetermined by chiral HPLC analysis.
