Table 3.

Spearman correlation coefficient rs and ρ-values for metabolic and radiomics features in 3D mode with tumour metabolic volume, tumour staging, and maximum diameter; cells signed with (*) are medium correlation where cells signed with (**) are high correlation

3D features	Diameter (rs)	Diameter (ρ)	AJCC staging (rs)	AJCC staging (ρ)	MTV (rs)	MTV (ρ)
SUVmean/std	0.5019	0.0029**	0.3242	0.0657*	0.6090	0.0002**
SUVmin (SUV)	–0.5439	0.0011**	–0.2844	0.1087	–0.5505	0.0009**
SUVmean (SUV)	0.3246	0.0654*	0.4177	0.0156*	0.5114	0.0024**
_SUVstd (SUV)	0.4400	0.0104*	0.3509	0.0453*	0.6123	0.0002**
SUVmax (SUV)	0.4882	0.0040*	0.4108	0.0176*	0.6928	< 0.0001**
SUVpeak 1 ml	0.4903	0.0038	0.3799	0.0292*	0.6801	< 0.0001**
TLG (ml)	0.7461	< 0.0001**	0.4556	0.0077*	0.9776	< 0.0001**
HISTO_Skewness	0.3281	0.0623*	0.1334	0.4592	0.4679	0.006*
HISTO_Kurtosis	0.2966	0.0937	–0.0407	0.8222	0.3382	0.0542*
HISTO_Entropy_log10	0.4500	0.0086*	0.3554	0.0424*	0.6230	0.0001**
HISTO_Energy	–0.4323	0.0120*	–0.3452	0.0491*	–0.5946	0.0003**
Sphericity (only for 3D ROI)	–0.2573	0.1483	–0.4117	0.0173*	–0.5003	0.0030**
SHAPE_Compacity ROI (nZ > 1)	0.7363	< 0.0001**	0.3128	0.0764*	0.9542	< 0.0001**
GLCM_Homogeneity	–0.2991	0.0908	–0.3118	0.0773*	–0.4602	0.007*
GLCM_Energy	–0.4090	0.0181*	–0.3576	0.041*	–0.5872	0.0003**
GLCM_Contrast	0.3269	0.0633*	0.3358	0.0561*	0.4773	0.0050*
GLCM_Correlation	0.6277	< 0.0001**	0.2483	0.1635	0.7614	< 0.0001**
GLCM_Entropy_log10	0.4323	0.0120*	0.3805	0.0289*	0.6096	0.0002**
GLCM_Dissimilarity	0.3145	0.0746*	0.3340	0.0575*	0.4766	0.0050*
GLRLM_SRE	0.1169	0.5190	0.2701	0.1285	0.2012	0.2615
GLRLM_LRE	–0.0875	0.6283	–0.2556	0.1511	–0.1310	0.4674
GLRLM_LGRE	–0.1273	0.4802	–0.2668	0.1333	–0.2707	0.1276
GLRLM_HGRE	0.3460	0.0486*	0.4115	0.0174*	0.5394	0.0012**
GLRLM_SRLGE	–0.1521	0.3982	–0.324	0.0658*	–0.3185	0.0708*
GLRLM_SRHGE	0.3314	0.0596*	0.4218	0.0145*	0.5124	0.0023**
GLRLM_LRLGE	–0.0087	0.9617	–0.1133	0.5303	–0.0745	0.6802
GLRLM_LRHGE	0.3883	0.0256*	0.4538	0.0080*	0.6380	< 0.0001**
GLRLM_GLNU	0.6943	< 0.0001**	0.2672	0.1328	0.8930	< 0.0001**
GLRLM_RLNU	0.7143	< 0.0001**	0.4324	0.0120*	0.9733	< 0.0001**
GLRLM_RP	0.1074	0.5519	0.2334	0.1911	0.1852	0.3023
NGLDM_Coarseness	–0.711	< 0.0001**	–0.3993	0.0213*	–0.9652	< 0.0001**
NGLDM_Contrast	–0.0054	0.9764	0.181	0.3135	0.0896	0.6201
NGLDM_Busyness	0.3197	0.0697*	0.0937	0.6041	0.4676	0.0061*
GLZLM_SZE	0.3018	0.0878*	0.46	0.0071*	0.3061	0.0831*
GLZLM_LZE	0.1057	0.5581	–0.1296	0.4722	0.1407	0.4348
GLZLM_LGZE	–0.311	0.0781*	–0.4422	0.0100*	–0.5043	0.0028**
GLZLM_HGZE	0.4122	0.0171*	0.4149	0.0163*	0.6243	0.0001**
GLZLM_SZLGE	–0.3756	0.0312*	–0.3683	0.0350*	–0.6233	0.0001**
GLZLM_SZHGE	0.4042	0.0197*	0.4110	0.0175*	0.5929	0.0003**
GLZLM_LZLGE	0.1910	0.2869	–0.0546	0.7627	0.2176	0.2239
GLZLM_LZHGE	0.1793	0.3180	–0.1036	0.5660	0.2654	0.1355
GLZLM_GLNU	0.6590	< 0.0001**	0.4915	0.0037*	0.9181	< 0.0001**
GLZLM_ZLNU	0.6412	< 0.0001**	0.4607	0.0070*	0.8590	< 0.0001**
GLZLM_ZP	0.1273	0.4802	0.2988	0.0912	0.1888	0.2926