Skip to main content
. 2021 Jan 25;6(2):e143596. doi: 10.1172/jci.insight.143596

Figure 8. Electron microscopy of duodenal mucosal biopsies in controls and DGE.

Figure 8

(A–D) Compared with healthy controls (A and B), there are fewer mitochondria, denoted with arrows (i.e., reduced mitochondrial density) in DGE (C and D). (E) A mitochondrion engulfed by a vacuole (arrows), and disintegrating cristae (arrowhead) in a patient with DGE. (F) Mitochondrial density in controls and DGE patients (analysis of 30 images in controls [n = 21] and DGE patient [n = 40], Wilcoxon test). Results were normalized by the mean value of the control samples set to 1 unit. (G) The Spearman correlation coefficients, represented by the color and size of the circles, between the expression of differentially expressed mtDNA OXPHOS genes and mitochondrial density (surrounded by black rectangle). Empty cells represent insignificant correlations (P value cut off = 0.05); DGE, diabetic gastroenteropathy; mtDNA, mitochondrial DNA; OXPHOS, oxidative phosphorylation. Total original magnification, 60,000×.