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. 2021 Jan 25;6(2):e134601. doi: 10.1172/jci.insight.134601

Figure 6. Echinatin is efficacious in DSS-induced colitis model.

Figure 6

(A and B) WT C57BL/6 mice were given 2.5% DSS in the drinking water in the presence or absence of echinatin (40 mg/kg), MCC950 (40 mg/kg), or the combination for 9 days. Body weights (A) and disease activity index (B) of the mice were measured (n=6 for each group). (C–E) Representative colon images (C), the colon lengths (D, n=6 for each group), and H&E-stained colon sections (E) were measured 10 days after treatment with DSS plus vehicle, echinatin (40 mg/kg), MCC950 (40 mg/kg), or the combination. Scale bar: 1 cm (C), 200 μm (E). (F and G) Representative IB analysis of active caspase-1 (F) and ELISA assay of IL-1β (G, n=6 for each group) in colon tissues. Data are expressed as mean ± SD. One-way ANOVA, followed by LSD post hoc test, was used to assess the differences of multiple groups (A, B, D, and G). ***P < 0.001.