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. 2021 Jan 25;6(2):e136114. doi: 10.1172/jci.insight.136114

Figure 6. 127-hi cells from people with T1D are predominantly memory cells with a Th2 bias.

Figure 6

The frequency of naive, CM, and EM cells in 127-hi cells or CD25– (CD25-neg) cells or total CD4+ T cells in PBMCs collected at baseline from patients with T1D was determined (n = 48). The pie charts show the mean of each subset within 127-hi (A), CD25– (B), and total CD4+ (C) cells, and the bar graphs show the mean ± SEM for each cell subset within each population. (D) In a separate experiment, PBMCs from patients with T1D (n = 21) collected at baseline were evaluated for the relative frequency of precommitted Th2 cells and precommitted Th1 cells (D) within 127-hi memory cells, CD25– memory cells, and CD4+ memory cells. Statistical differences between groups was calculated using ANOVA (P < 0.0001) followed by Sidak’s multiple comparison test. Data are shown as mean ± SEM. ****P < 0.0001.