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. 2021 Jan 25;6(2):e135626. doi: 10.1172/jci.insight.135626

Figure 1. Characterization of mice with a liver-specific double KO of Cpt2 and Atgl.

Figure 1

(A) Schematic of the relationship between TG hydrolysis and fatty acid β-oxidation. (B) mRNA of Atgl and Cpt2 under fed and fasted conditions in the livers of control, Atgl-Cpt2L–/– (DKO), AtglL–/– (Atgl), Cpt2L–/– (Cpt2), and Pparα-KO mice (n = 6/genotype). (C) Western blot for Atgl and Cpt2 in livers of control, Atgl, Cpt2, DKO, and Pparα-KO mice. (D) Body weights of 9-week-old male and female mice fed a chow diet (males, n = 8–16; females, n = 8–10). (E) Liver weights of male mice under fed and fasted conditions (n = 10–16). ACSL, acyl-CoA synthetase long chain.