Table 3.
Three patients with movement disorders.
| Patient | 7 | 19 | 20 |
|---|---|---|---|
| Age, M/F, ethnicity, COVID-19 diagnosis | 57, M, White, Definite | 86, F, White, Definite | 86, M, White, Probable |
| Final neurological diagnosis | Myoclonus | Opsoclonus myoclonus | Generalized rest myoclonus affecting lower face and whole body |
| Blood results at admission | Hemoglobin 104 g/l Lymphocyte count 0.56 Neutrophil count 3.22 Platelet count 223 CRP 409 mg/L D-dimer; 17390 Ferritin; 916 Creatinine 84 umol/L PT 12.5 s |
Hemoglobin 109 g/l Lymphocyte count 0.86 Neutrophil count 10.2 Platelet count 271 CRP 5 mg/L D-dimer; NR Ferritin; NR Creatinine 80 umol/L PT; NR |
Hemoglobin 97 g/l Lymphocyte count 0.76 Neutrophil count 4.51 Platelet count 302 CRP 35 mg/L, ESR 105 mm/hr D-dimer; NR Ferritin; NR Creatinine 139 umol/L PT; NR |
| Brain imaging | CT: No acute abnormality | MRI: No acute abnormality | MRI: No acute abnormality Electroencephalography: Normal |
| CSF examination | Not performed | White cell none, red cell none, protein; 46.8 mg/dl, glucose; 3.9 mmol/L. paired serum glucose; NR. Viral PCR for SARS-CoV-2/enterovirus/HSV negative. NMDA-R/CASPR2/LGi-1/Glycine receptor antibodies all negative |
White cell none, red cells 265, protein; 166.7 mg/dl, glucose 3.6 mmol/L, paired serum glucose; NR. Oligoclonal bands present in serum and CSF. Viral PCR for SARS-CoV-2/enterovirus/HSV negative. NMDA-R/CASPR2/LGi-1/Glycine receptor antibodies all negative |
| Neurological treatments; recovery | Diazepam | Levetiracetam and clonazepam | Clonazepam |
| Outcome status | Full recovery | Partial recovery with neurological deficits; Moderate disability mRS 3 | Full recovery |
M, male; F, female; NR, no result; CRP, C-Reactive protein; mRS, modified Rankin Score; NMDA-R, N-methyl-D-aspartate Receptor antibodies; ESR, Erythrocyte sedimentation rate; PCR, polymerase chain reaction; LGi-1, Leucine-rich glioma inactivated-1; CASPR2, contactin-associated protein-like 2. PT, Prothrombin time; CT, computed tomography. MRI, magnetic resonance imaging, Lymphocyte, neutrophil and platelet count, numbers x 10 E9/L. The bold values highlight abnormal values.