Table 4.
Three patients with disorders of the peripheral nervous system.
| Patient | 13 | 23 | 26 |
|---|---|---|---|
| Age, M/F, ethnicity, COVID-19 diagnosis | 67, M, White, Definite | 58, F, White, Probable | 58, M, White, Definite |
| Final neurological diagnosis | Guillain-Barré syndrome | Atypical acute inflammatory demyelinating polyneuropathy | Brachial plexopathy 2. Bilateral hearing loss |
| Blood results at admission | Hemoglobin 133 g/l Lymphocyte count 0.93 Neutrophil count 3.81 Platelet count 242 CRP 112 mg/L D-dimer; NR Ferritin; 295 Creatinine 58 umol/L PT; NR |
Hemoglobin 85 g/l Lymphocyte count 0.48 Neutrophil count 5.19 Platelet count 178 CRP 16 mg/L D-dimer; NR Ferritin 340 ug/l Creatinine 140 umol/L PT 11.4 s |
Hemoglobin 101 g/l Lymphocyte count 1.24 Neutrophil count 16.36 Platelet count 224 CRP 351 mg/L D-dimer 9251 ug/l Ferritin 800 ug/l Creatinine 62 umol/L PT 11.5 s |
| Brain imaging | Not performed | MRI Brain and spinal cord: No acute abnormality | CT brain: No acute abnormality |
| Nerve conduction study | Segmental demyelinating peripheral neuropathy | Sensory and motor axonal neuropathy | Not performed during the acute SARS-CoV2 infection |
| CSF examination | Red cells: 1770, white cells: none; protein; 155.6 mg/dl, glucose; 4.2, Paired blood glucose; 6.6 mmol/L; Viral PCR for enterovirus/HSV negative | Red cells 8; White cells: none, protein; 340.1 mg/dl, glucose; 4.2, Paired blood glucose; 6.6 mmol/L; Oligoclonal bands negative. Viral PCR for SARS-CoV-2/enterovirus/HSV negative. NMDA-R/CASPR2/LGi-1/Glycine receptor antibodies all negative |
Not performed |
| Neurological treatments; recovery | Intravenous Immunoglobulin | Intravenous Methylprednisolone, Levetiracetam & Sodium Valproate (seizures) | No specific treatment administered (neurological disorder identified after ventilation support in critical care) |
| Outcome status | Recovery with slight disability; mRS 1 | Partial recovery with neurological deficits; mRS 4 | Partial recovery with slight disability; mRS 2 |
M, male; F, female; NR, no result; CRP, C-Reactive protein; mRS, modified Rankin Score; NMDA-R, N-methyl-D-aspartate Receptor antibodies; PCR, polymerase chain reaction; LGi-1, Leucine-rich glioma inactivated-1; CASPR2, contactin-associated protein-like 2. PT, Prothrombin Time; CT, computed tomography. MRI, magnetic resonance imaging; Lymphocyte, neutrophil and platelet count, numbers x 10 E9/L. The bold values highlight abnormal value.