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. Author manuscript; available in PMC: 2021 Mar 5.
Published in final edited form as: Chromosome Res. 2019 Nov 9;27(4):345–364. doi: 10.1007/s10577-019-09617-x

Fig. 3.

Fig. 3

Schematic representation of alternative/microhomology-mediated end joining. Alternative/microhomology-mediated end joining acts as a back up pathway for DSBs repair, by annealing 2–20-bp stretches of overlapping bases flanking the DSBs (all alternative pathways does not require microhomology). MRE11-RAD50-XRS2? complex [MRN complex; MRE11-RAD50-XRS2], CtBP-interacting protein (CtIP), and poly(ADP-ribose) polymerase 1 (PARP1) resect the DNA ends and gaps are filled by DNA polymerase theta (Polθ), ligated by Lig3, and mediated by XRCC1