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. 2021 Feb 22;6(4):e139946. doi: 10.1172/jci.insight.139946

Figure 1. Seven-day HFD causes WAT insulin resistance reflected by reductions in WAT glucose uptake and insulin’s suppression of WAT lipolysis.

Figure 1

(A) Plasma NEFA under basal (overnight fasting) and hyperinsulinemic-euglycemic clamp conditions. (B) Insulin’s suppression of plasma NEFA during the clamp. (C and D) Whole-body glycerol turnover and its suppression by insulin during the hyperinsulinemic-euglycemic clamp. (E and F) Whole-body fatty acid turnover and its suppression by insulin during the hyperinsulinemic-euglycemic clamp. (G) Insulin-stimulated WAT glucose uptake. In all panels, data are the mean ± SEM of n = 7–10 per group, with comparisons by 2-tailed unpaired Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001.