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. 2021 Feb 22;6(4):e143324. doi: 10.1172/jci.insight.143324

Figure 5. I154T-mGlu7 expression is reduced in vivo at the posttranscriptional level.

Figure 5

(A) Western blot of total protein lysate from cortex of Grm7+/+ (+/+), Grm7I154T/+ (I154T/+), and Grm7I154T/I154T (I154T/I154T) mice. Arrows indicate mGlu7 dimer and monomer bands. (B and C) Quantification of the mGlu7 dimer band (B) and monomer band (C) across 3 brain regions. Two-way ANOVA with Dunnett’s comparisons to Grm7+/+. *P < 0.05, ****P < 0.0001. (D) Grm7 mRNA transcript expression across each brain region. No significant difference by 2-way ANOVA. For all panels, n = 4 mice per genotype (2 male, 2 female). mGlu7, metabotropic glutamate receptor subtype 7; CTX, cortex; HPC, hippocampus; STR, striatum.