Table 3.

Main interactions of the compounds with the amino acids of the respective enzyme (ascending order, non-H-bonding interactions are in italic; equal residues (bold) of binding of miglitol and 8 or 16, respectively)

	Geobacillus sp. (α-glucosidase)	Baker’s yeast (α-glucosidase)	Rice (β-glucosidase)	White clover (α-galactosidase)	E. Coli (β-galactosidase)
8	Gly62, Gln167, Phe163	Gln67, Pro66, Glu405, Glu408, Trp468	Asn190, Phe277, Ile344	Trp16, Asn17, Trp108, Arg181, Ile186,	Asn102, Gln537, His540, Trp568, Phe601
16	Gly259, Phe282, Arg411,	Pro66, Glu405, Lys406, Tyr407, Arg413, Trp468	Gln33, Lys58, Lys60, Asn182, Thr196, His256, Gln345, Trp454,	Trp16, Ile23, Cys21, Trp164, Ile186,	Asn102, Gly489, Val515, Lys517, Gln537, His540, Trp568,
Miglitol	Gly145, Arg197, Ser224, His325	Lys466, Trp468	Lys58, His256, Gly274, Trp369, Trp454	Trp16, His18, Lys104, Trp164, Asn222	Asn102, Gly489, Lys517, Gln537