Table 1.

Human diseases related to genes with a signature of positive selection in the ancestor of cetaceans and baleen whales. The information was obtained from GeneCards (https://www.genecards.org/).

branch		diseases associated
ancestor Cetacea	CXCR2	autosomal recessive severe congenital neutropenia—neutrophil migration—immune system
ancestor Mysticeti	ADAMTS8	diseases of glycosylation—lung neoplasm
	ANXA1	anti-inflammatory activity; hairy cell leukaemia and penis squamous cell carcinoma
	DAB2	malignant epithelial mesothelioma—hypercholesterolaemia autosomal recessive—ovarian carcinoma
	DSC3	hypotrichosis—recurrent skin vesicles—subcorneal pustular dermatosis
	EPHA2	cataract 6, multiple types—early-onset posterior subcapsular cataract
	TMPRSS11A	iron-refractory iron deficiency anaemia—ichthyosis follicular