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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2020 Jul 12;13(8):e008296. doi: 10.1161/CIRCEP.120.008296

Figure 1:

Figure 1:

Diet-induced obese (DIO) mice are prone to atrial fibrillation (AF). The association between obesity and pacing-induced AF was examined in wild-type (lean) control, and DIO mice. A: Photograph showing the obesity phenotype in control, and DIO mice. B: Weights in control and DIO mice. Bars represent mean weight (g) in each group. Red dashed line represents the 33g threshold for obesity. C: Average weight (g) of mice who received high fat diet (HFD) over 10 weeks duration. D: Atrial electrograms showing sinus rhythm at baseline (top), pacing-induced AF in DIO mice (middle) and sinus rhythm restoration in DIO mice (bottom). E: Incidence of AF among the 2 groups. F: Burden (duration, s) of pacing-induced AF in DIO (N=24) and control (N=16) mice. G: Increase in burden (duration, s) of pacing-induced AF with increase in weight. *P<0.05, **P<0.01; ***P<0.001, ****P<0.0001.