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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2020 Jul 12;13(8):e008296. doi: 10.1161/CIRCEP.120.008296

Figure 3:

Figure 3:

The cardiac sodium current (INa) is reduced in DIO mice. Obese mice have reduced sodium channel current (INa) versus controls. A: Western blot showing Nav1.5 expression in atria of control, and DIO mice (N=7 hearts). B: Quantification of Nav1.5 expression among the 2 groups (N=7 hearts). C: Atrial sections immunostained for Nav1.5 (left), DAPI (center), and merged (right). D: Quantification of corrected total cell fluorescence (CTCF) of Nav1.5 protein in immunostained samples (n=14 cells). E: Sodium current and voltage relationship (I-V curves) in control and DIO mice (n=6 atrial cells). F: Comparisons of peak INa at −50mV in control (n=6 cells) and DIO (n=6 cells) mice. G: Steady-state inactivation and activation of the sodium currents in control (n=6 cells) and DIO mice (n=6 cells). H: DIO mice did not significantly alter sodium windows currents compared to control. *P<0.05, **P<0.01; ***P<0.001, ****P<0.0001.