Table 1.

Significant clusters of BOLD activation in insula and ACC for main effects and interactions of uncertainty (certain/uncertain) and incongruence (congruent/incongruent). X, Y, Z coordinates are in MNI space. Cluster information for main effects is based on directional contrasts (t-tests) and cluster information for interactions is based on non-directional contrasts (F-tests).

contrast	anatomical label(s)	side	cluster size	p-value	peak activation (Z-score)	X	Y	Z
certain > uncertain	insular cortex; lateral orbitofrontal cortex	left	720	0.000271	4.37	−32	20	−16
certain > uncertain	insular cortex; lateral orbitofrontal cortex	right	479	0.00277	3.95	32	28	−2
certain > uncertain	paracingulate gyrus	—	1392	<0.001	4.14	−4	24	42
incongruent > congruent	insular cortex; lateral orbitofrontal cortex	right	409	0.00863	3.89	36	24	−2
incongruent > congruent	cingulate gyrus, anterior division; paracingulate gyrus	—	1644	<0.001	4.15	−6	16	34
uncertainty × incongruence	insular cortex; lateral orbitofrontal cortex	left	919	<0.001	4.44	−32	24	2
uncertainty × incongruence	insular cortex; lateral orbitofrontal cortex	right	638	0.000467	3.33	42	20	2
uncertainty × incongruence	paracingulate gyrus; cingulate gyrus, anterior division	—	2548	<0.001	4.85	0	20	42