Table 1.
Patient Characteristics and their Relationship with Other-Cause Mortality
| Variable | Levels | %^ | Unadjusted SHR (95% CI) | P-value | Adjusted SHR (95% CI) | P-value |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age at Diagnosis | >80 yr | 23.7 | Reference | Reference | ||
| 65–70 yr | 14.9 | 0.22 (0.16–0.29) | <.001 | 0.24 (0.18–0.35) | <.001 | |
| 71–75 yr | 33.6 | 0.31 (0.26–0.38) | <.001 | 0.38 (0.30–0.46) | <.001 | |
| 76–80 yr | 27.8 | 0.42 (0.35–0.51) | <.001 | 0.47 (0.39–0.59) | <.001 | |
| Married | No | 36.1 | Reference | Reference | ||
| Yes | 63.9 | 0.67 (0.59–0.80) | <.001 | 0.87 (0.74–1.03) | 0.108 | |
| Race/Ethnicity | Non-Hispanic White | 83.7 | Reference | Reference | ||
| Black | 9.5 | 1.36 (1.07–1.74) | 0.013 | 0.94 (0.71–1.25) | 0.665 | |
| Hispanic | 2.7 | 0.51 (0.26–0.98) | 0.043 | 0.43 (0.22–0.86) | 0.017 | |
| Other | 4.1 | 0.89 (0.60–1.35) | 0.603 | 0.55 (0.36–0.86) | 0.008 | |
| Rural/Urban | Rural | 13.1 | Reference | Reference | ||
| Urban | 86.9 | 0.79 (0.64–0.98) | 0.035 | 1.03 (0.81–1.32) | 0.787 | |
| U.S. Region, 2010 Census | South | 28.0 | Reference | Reference | ||
| Northeast | 17.8 | 0.74 (0.58–0.94) | 0.013 | 0.80 (0.61–1.04) | 0.098 | |
| Midwest | 11.0 | 1.14 (0.58–1.56) | 0.295 | 1.05 (0.81–1.35) | 0.722 | |
| West | 43.2 | 0.71 (0.59–0.86) | <.001 | 0.82 (0.66–1.01) | 0.059 | |
| Poverty Indicator | 0%-<5% | 25.2 | Reference | Reference | ||
| 5% to <10% | 25.6 | 1.18 (0.93–1.49) | 0.166 | 1.04 (0.81–1.32) | 0.765 | |
| 10% to <20% | 29.1 | 1.45 (1.16–1.79) | 0.001 | 1.17 (0.92–1.50) | 0.198 | |
| 20% to 100% | 19.0 | 1.67 (1.32–2.12) | <.001 | 1.14 (0.86–1.50) | 0.370 | |
| Unknown/Missing | 1.1 | 2.17 (1.10–4.26) | 0.025 | 1.82 (0.90–3.68) | 0.095 | |
| Education | 4-year or more college graduate | 29.8 | Reference | Reference | ||
| High school graduate or GED | 26.3 | 1.27 (1.01–1.59) | 0.041 | 1.03 (0.81–1.29) | 0.840 | |
| Some college or 2-year degree | 21.7 | 1.16 (0.91–1.48) | 0.216 | 1.05 (0.82–1.34) | 0.719 | |
| 8th grade or less, some high school | 19.5 | 1.98 (1.59–2.46) | <.001 | 1.24 (0.97–1.59) | 0.094 | |
| Unknown/Missing | 2.8 | 2.05 (1.32–3.18) | 0.001 | 1.26 (0.80–2.00) | 0.325 | |
| Cancer Information | ||||||
| AJCC Stage | Stage I/ II | 82.8 | Reference | Reference | ||
| Stage III | 4.9 | 0.68 (0.44–1.07) | 0.094 | 0.92 (0.58–1.45) | 0.714 | |
| Stage IV | 7.2 | 2.21 (1.60–3.04) | <.001 | 1.50 (1.05–2.15) | 0.027 | |
| Unknown/Missing | 5.1 | 2.35 (1.73–3.18) | <.001 | 1.50 (1.06–2.14) | 0.024 | |
| PSA | <10.0 ng/ml | 54.2 | Reference | Reference | ||
| 10.0–20.0 ng/ml | 14.5 | 1.95 (1.57–2.41) | <.001 | 1.50 (1.20–1.88) | <.001 | |
| >20.0 ng/ml | 12.4 | 2.39 (1.89–3.03) | <.001 | 1.55 (1.19–2.02) | 0.001 | |
| Unknown/Missing | 18.9 | 1.99 (1.63–2.44) | <.001 | 1.31 (1.05–1.63) | 0.018 | |
| Gleason Score | 0–6 | 35.3 | Reference | Reference | ||
| 7 | 36.2 | 0.86 (0.71–1.04) | 0.115 | 0.80 (0.66–0.97) | 0.026 | |
| 8–10 | 21.4 | 1.45 (1.17–1.76) | <.001 | 1.09 (0.87–1.36) | 0.468 | |
| Unknown/Missing | 7.1 | 2.38 (1.77–3.21) | <.001 | 1.34 (0.94–1.90) | 0.106 | |
| Claims-based Health Measures | ||||||
| NCI Comorbidity Index Score | 0 | 61.9 | Reference | Reference | ||
| 1 | 22.4 | 1.59 (1.32–1.91) | <.001 | 1.37 (1.13–1.66) | 0.001 | |
| 2 | 9.5 | 1.88 (1.47–2.41) | <.001 | 1.46 (1.13–1.90) | 0.005 | |
| 3+ | 6.2 | 2.38 (1.98–3.16) | <.001 | 1.51 (1.12–2.04) | 0.007 | |
| Frailty Indicator Count | 0 | 68.6 | Reference | Reference | ||
| 1 | 27.5 | 2.01 (1.70–2.37) | <.001 | 1.50 (1.26–1.79) | <.001 | |
| 2+ | 4.0 | 3.89 (2.91–5.22) | <.001 | 2.74 (2.01–3.75) | <.001 | |
| Patient-reported Health Measures | ||||||
| Smoking | No | 90.6 | Reference | Reference | ||
| Yes | 9.4 | 1.46 (1.15–1.87) | 0.002 | 1.40 (1.08–1.81) | 0.010 | |
| Mental Health | Excellent | 34.3 | Reference | Reference | ||
| Very Good | 33.0 | 1.53 (1.27–1.89) | <.001 | 1.16 (0.93–1.46) | 0.211 | |
| Good | 24.1 | 2.05 (1.66–2.54) | <.001 | 1.33 (1.04–1.70) | 0.023 | |
| Fair/Poor | 8.7 | 2.42 (1.84–3.18) | <.001 | 1.13 (0.81–1.57) | 0.482 | |
| Overall Health | Excellent | 10.9 | Reference | Reference | ||
| Very Good | 32.2 | 1.44 (1.00–2.09) | 0.050 | 1.25 (0.85–1.84) | 0.250 | |
| Good | 36.4 | 2.11 (1.48–3.00) | <.001 | 1.44 (0.98–2.12) | 0.066 | |
| Fair/Poor | 20.6 | 3.77 (2.63–5.39) | <.001 | 2.24 (1.48–3.40) | <.001 | |
| Functional Deficit | No | 75.6 | Reference | Reference | ||
| Yes | 24.4 | 1.91 (1.62–2.25) | <.001 | 1.16 (0.96–1.41) | 0.112 | |
^
Made not sum to 100% due to rounding.