Table 2. EC₅₀ concentrations against MeV L of resistance mutations induced by viral adaptation to ERDRP-0519 and GHP-88309, respectively.

Binding kinetics (K_D) between MeV L₁₇₀₈ or MeV L₁₇₀₈ harboring resistance mutations and ERDRP-0519 or GHP-88309 are shown.

	ERDRP-0519				GHP-88309
L mutation	EC50 [μM]	95% confidence intervals [μM]	fold change to WT	KD [μM]	EC50 [μM]	95% confidence intervals [μM]	fold change to WT	KD [μM]
WT	0.13	0.11–0.15	-	0.079	2.40	1.94–2.98	-	6.2*
H589Ya	5.54	4.62–6.64	44.6	59	3.91	1.87–8.17	1.8	n.d.
S768Aa	3.72	3.35–4.12	29.1	33	1.26	0.93–1.71	0.6	n.d.
T776Aa	10.67	9.41–12.10	76.6	n.d.	2.39	1.45–3.94	1.1	n.d.
L1170Fa	2.36	1.99–2.79	16.9	48	2.41	1.70–3.4	0.7	n.d.
V1239Aa	3.97	3.34–4.72	29.8	n.d.	2.03	1.34–3.07	0.7	n.d.
E858Db	0.10	0.08–0.11	0.7	n.d.	15.04*	10.69–19.68*	6.7	8.6*
I1009Fb	0.05	0.04–0.07	0.3	n.d.	18.62*	13.78–25.51*	8.3	68.3*
T1010Nb	0.18	0.15–0.21	1.5	n.d.	8.36*	4.40–15.71*	3.8	n.d.
Y1106Sb	0.11	0.09–0.14	0.6	n.d.	>100*	>100*	>50	>300*

* reported previously [36].

a resistance mutation induced by ERDRP-0519.

b resistance mutation induced by GHP-88309.