Table 1. Baseline characteristics of recruited datasets for adult and paediatric patient.

	GSE54514	GSE57065	GSE95233	GSE64456	GSE66099	GSE72829
Patient type	Adult	Adult	Adult	Pediatric	Pediatric	Pediatric
Age, mean (yr) a,b	≥18, 60.3	≥18, 62	≥18, 65	≤2 mo, 29 d	≤10, 3.7	≤17, 1.9 mo
Sex (male %)b	40	67.9	65	52	58	62
Nonsurvivor (%)	25.7	17.9 (28 d)	NA	NA	16.3	19.2
Cohort description	ICU with sepsis or	ICU with	ICU with	ED with sepsis	PICU with sepsis or	Discovery group
	septic shock	septic shock	septic shock	(PECARN study)	septic shock	(IRIS study)
Severity evaluation	APACHEII	SOFA	SOFA	YOSb	PRISM	NA
Control (n)	18	25	22	19	49	52
Sepsis or septic shock (n)	35	28	51	89	198	94
Randomized selection without replacement (septic shock)	18	25	22	-	-	-
Randomized selection without replacement (sepsis)	-	-	-	18	49	52
Measured frequency, frequency (time points)	5 (1, 2, 3, 4, 5 d)	3 (0, 24, 28 hr)	3 (1–2, 3–4, 7–10 d)	1	1	1
Recruited time pointsc	0–24 hr	0–24 hr	1–2 d	NA	0–24 hr	5 d
Platform	Illumina, GPL6947	Affymetrix, GPL570	Affymetrix, GPL570	Illumina, GPL10558	Affymetrix, GPL570	Illumina, GPL10558
Reference	[11]	[12]	[16]	[13]	[14]	[15]

ED, emergency department; ICU, intensive care unit; NA, data not available; hr, hour; d, day; APACHEII, acute physiology and chronic health evaluation II; SOFA, sequential (sepsis related) organ failure assessment.

^aGSE57065 and GSE72829 were summarized using median age.

^b Percent of male and age are summarized data derived from the previous studies, which could be different from the analysis performed in this study. The sepsis patient was randomly selected corresponding to the number of the control cases.

^cYOS, Yale observation score (6–30).