Table 2. Differentially expressed gene analysis between control and sepsis followed by gene set pathway analysis^a.

	GSE54514	GSE57065	GSE95233	GSE64456	GSE66099	GSE72829
Patient type	Adult	Adult	Adult	Pediatric	Pediatric	Pediatric
Control cases (n)	18	25	22	19	49	52
Sequential selection of sepsis cases (n)	18	25	22	19	49	52
Differentially expressed Genes (n)	176	7885	6784	3123	8229	7463
Up regulated pathway (n)	0	60	44	13	78	51
Down regulated pathway (n)	0	33	33	16	33	15
Up regulated immune pathway		C, Fc, RIG	C, Fc	C, Fc, NK, K, TLR	APC, C, CXC & etc, Fc, IgA,	BCR, C, Fc, CXC & etc, LK, NK, TLR
Down regulated immune pathway		APC, TCR, H, K	APC, BCR, CXC & etc, IgA, TCR	APC, IgA, TCR	H, TCR	APC, IgA, TCR

^aDifferentially expressed gene was selected based on FDR (P<0.01).

APC, Antigen processing and presentation; BCR, B cell receptor signaling; C, Complement and coagulation; CXC & etc, chemokine signaling; Fc, Fc gamma R mediated phagocytosis or Fc epsilon RI signaling; H, hematopoietic cell lineage; IgA, intestinal immune network for IgA production; LM, leukocyte endothelial migration; NK, NK cell mediated cytotoxicity; RIG, RIG-I like receptor signaling; TLR, Toll like receptor signaling; TCR, T cell receptor signaling.