Table 3. Network topological parameters from gene expression data from GEO dataset for adult and paediatric patient.

	GSE54514		GSE57065		GSE95233		GSE95233-1		GSE64456		GSE66099		GSE72829
Patient type	Adult		Adult		Adult		Adult		Pediatric		Pediatric		Pediatric
Disease type	Control	septic shock	control	septic shock	control	septic shock	survivor	non survivor	Control	sepsis	Control	sepsis	Control	sepsis
Clustering coefficient	0.319	0.323	0.328	0.280	0.328	0.367	0.390	0.337	0.367	0.390	0.337	0.388	0.381	0.435
Network density	0.013	0.016	0.012	0.010	0.012	0.039	0.026	0.014	0.039	0.026	0.014	0.012	0.030	0.034
Network heterogeneity	1.039	1.142	1.151	1.172	1.151	1.504	1.358	1.193	1.504	1.358	1.193	1.091	1.249	1.129
Connected components	27	30	42	61	42	34	33	47	34	33	47	32	16	25
Network diameter	19	17	14	15	14	12	19	11	12	19	11	14	13	9
Network centralization	0.059	0.079	0.103	0.048	0.103	0.196	0.113	0.075	0.196	0.113	0.075	0.078	0.148	0.121
Shortest path	160514	80598	59638	17222	59638	142640	121152	11730	142640	121152	11730	36902	38092	22532
Characteristic path length	7.418	5.267	5.276	5.088	5.276	3.862	7.211	3.482	3.862	7.211	3.482	4.705	3.92	2.824
Average degree, <k>	5.93	7.42	5.30	3.64	5.30	17.87	11.71	4.04	17.87	11.71	4.04	4.50	8.43	10.27
Number of nodes, N	464	453	426	367	426	457	448	297	457	448	297	380	284	299
Degree correlation, μ	0.489	0.508	0.422	0.810	0.422	0.403	0.715	0.546	0.403	0.715	0.546	0.210	0.475	0.346
Modularity, Mc	0.743	0.662	0.644	0.806	0.644	0.198	0.581	0.694	0.198	0.581	0.694	0.745	0.434	0.603

GSE95233-1 indicates survivors (n = 16) and non-survivors (n = 16) among sepsis patients.