Table 1. Genotypic and allelic distributions of six functional SNPs in HOTAIR gene between Taiwanese endometriosis patients and controls.
| SNPsa | Genotype/allele | No. (%) of patients | HWEa | No. (%) of controls | HWEa | p-valueb | Corrected p-valuec | OR (95% CI)a |
|---|---|---|---|---|---|---|---|---|
| rs1838169 | GG | 18 | 0.3391 | 7 | 0.7331 | 0.0419* | 0.2514 | 2.8211 (1.1322–7.0293) |
| GC | 73 | 58 | 1.3808 (0.8928–2.1356) | |||||
| CC | 103 | 113 | 1.00 Reference | |||||
| G | 109 (28.09%) | 67 (18.82%) | 0.0029** | 0.0174* | 1.6852 (1.1924–2.3816) | |||
| C | 279 (71.91%) | 289 (81.18%) | 1.00 Reference | |||||
| rs4511324 | GG | 15 | 0.2989 | 5 | 0.3718 | 0.0737 | 0.4422 | 3.1513 (1.1107–8.9406) |
| GA | 70 | 63 | 1.1671 (0.7646–1.7816) | |||||
| AA | 119 | 125 | 1.00 Reference | |||||
| G | 100 (24.51%) | 73 (18.91%) | 0.0560 | 0.1120 | 1.3921 (0.9906–1.9564) | |||
| A | 308 (75.49%) | 313 (81.09%) | 1.00 Reference | |||||
| rs4512901 | CC | 15 | 0.2989 | 6 | 0.6116 | 0.1232 | 0.7392 | 2.6261 (0.9861–6.9934) |
| CA | 70 | 62 | 1.1860 (0.7760–1.8124) | |||||
| AA | 119 | 125 | 1.00 Reference | |||||
| C | 100 (24.51%) | 74 (19.17%) | 0.0693 | 0.4158 | 1.3689 (0.9750–1.9219) | |||
| A | 308 (75.49%) | 312 (80.83%) | 1.00 Reference | |||||
| rs4759313 | TT | 26 | 0.365 | 14 | 0.7655 | 0.1421 | 0.8526 | 2.0186 (0.9937–4.1008) |
| TA | 85 | 79 | 1.1695 (0.7706–1.7748) | |||||
| AA | 92 | 100 | 1.00 Reference | |||||
| T | 137 (33.74%) | 107 (27.72%) | 0.0664 | 0.3984 | 1.328 (0.9805–1.7985) | |||
| A | 269 (66.26%) | 279 (72.28%) | 1.00 Reference | |||||
| rs10783616 | CC | 25 | 0.4608 | 14 | 0.7864 | 0.1557 | 0.9342 | 1.9819 (0.9715–4.0432) |
| CG | 85 | 79 | 1.1942 (0.7868–1.8125) | |||||
| GG | 91 | 101 | 1.00 Reference | |||||
| C | 135 (33.58%) | 107 (27.58%) | 0.0672 | 0.4032 | 1.3278 (0.9798–1.7996) | |||
| G | 267 (66.42%) | 281 (72.42%) | 1.00 Reference | |||||
| rs17720428 | GG | 16 | 0.2359 | 4 | 0.2141 | 0.0286* | 0.1716 | 4.1333 (1.3432–12.7195) |
| GT | 71 | 63 | 0.9169 (0.6012–1.3983) | |||||
| TT | 120 | 124 | 1.00 Reference | |||||
| G | 103 (24.88%) | 71 (18.59%) | 0.0318* | 0.1908 | 1.4507 (1.0318–2.0397) | |||
| T | 311 (75.12%) | 311 (81.41%) | 1.00 Reference |
aAbbreviations: SNP, single-nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium testing; OR, odds ration; 95% CI, 95% confidence interval.
bp-values were calculated by χ2 test.
cBonferroni correction was applied to get the corrected p-value, which equals to p-value×6. Statistical significance
*, p-value <0.05
**, p-value <0.01
***, p-value <0.001.