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. 2021 Mar 5;16(3):e0248168. doi: 10.1371/journal.pone.0248168

Table 2. Dominant and recessive effects of the selected SNPs in HOTAIR gene between Taiwanese endometriosis patients and controls.

SNPsa Genotype No. (%) of patients No. (%) of controls p-valueb Corrected p-valuec OR (95% CI)a
rs1838169 GC+GG 91 65 0.0424* 0.2544 1.5359 (1.0138–2.3271)
CC 103 113 1.00 Reference (dominant)
GG 18 7 0.0397* 0.2382 2.4984 (1.0177–6.1331)
CC+GC 176 171 1.00 Reference (recessive)
rs4511324 GA+GG 85 68 0.1884 1.0000 1.3130 (0.8750–1.9703)
AA 119 125 1.00 Reference
GG 15 5 0.0302* 0.1812 2.9841 (1.0631–8.3761)
AA+GA 189 188 1.00 Reference
rs4512901 CA+CC 85 68 0.1884 1.0000 1.3130 (0.8750–1.9703)
AA 119 125 1.00 Reference
CC 15 6 0.0754 0.4524 2.3545 (0.8938–6.2026)
AA+CA 189 187 1.00 Reference
rs4759313 TA+TT 111 93 0.1963 1.0000 1.2973 (0.8739–1.9259)
AA 92 100 1.00 Reference
TT 26 14 0.0668 0.4008 1.8781 (0.9495–3.7151)
AA+TA 177 179 1.00 Reference
rs10783616 CG+CC 110 93 0.1773 1.0000 1.3128 (0.8839–1.9498)
GG 91 101 1.00 Reference
CC 25 14 0.0822 0.4935 1.8263 (0.9193–3.6283)
GG+CG 176 180 1.00 Reference
rs17720428 GG+GT 87 67 0.1552 0.9314 1.3418 (0.8944–2.0129)
TT 120 124 1.00 Reference
GG 16 4 0.0101* 0.0608 3.9162 (1.2854–11.9317)
TT+GT 191 187 1.00 Reference

aAbbreviations: SNP, single-nucleotide polymorphism; OR, odds ration; 95% CI, 95% confidence interval.

bp-values were calculated by χ2 test.

cBonferroni correction was applied to get the corrected p-value, which equals to p-value×6. Statistical significance

*, p-value <0.05

**, p-value <0.01

***, p-value <0.001.