Table 2. Dominant and recessive effects of the selected SNPs in HOTAIR gene between Taiwanese endometriosis patients and controls.
SNPsa | Genotype | No. (%) of patients | No. (%) of controls | p-valueb | Corrected p-valuec | OR (95% CI)a |
---|---|---|---|---|---|---|
rs1838169 | GC+GG | 91 | 65 | 0.0424* | 0.2544 | 1.5359 (1.0138–2.3271) |
CC | 103 | 113 | 1.00 Reference (dominant) | |||
GG | 18 | 7 | 0.0397* | 0.2382 | 2.4984 (1.0177–6.1331) | |
CC+GC | 176 | 171 | 1.00 Reference (recessive) | |||
rs4511324 | GA+GG | 85 | 68 | 0.1884 | 1.0000 | 1.3130 (0.8750–1.9703) |
AA | 119 | 125 | 1.00 Reference | |||
GG | 15 | 5 | 0.0302* | 0.1812 | 2.9841 (1.0631–8.3761) | |
AA+GA | 189 | 188 | 1.00 Reference | |||
rs4512901 | CA+CC | 85 | 68 | 0.1884 | 1.0000 | 1.3130 (0.8750–1.9703) |
AA | 119 | 125 | 1.00 Reference | |||
CC | 15 | 6 | 0.0754 | 0.4524 | 2.3545 (0.8938–6.2026) | |
AA+CA | 189 | 187 | 1.00 Reference | |||
rs4759313 | TA+TT | 111 | 93 | 0.1963 | 1.0000 | 1.2973 (0.8739–1.9259) |
AA | 92 | 100 | 1.00 Reference | |||
TT | 26 | 14 | 0.0668 | 0.4008 | 1.8781 (0.9495–3.7151) | |
AA+TA | 177 | 179 | 1.00 Reference | |||
rs10783616 | CG+CC | 110 | 93 | 0.1773 | 1.0000 | 1.3128 (0.8839–1.9498) |
GG | 91 | 101 | 1.00 Reference | |||
CC | 25 | 14 | 0.0822 | 0.4935 | 1.8263 (0.9193–3.6283) | |
GG+CG | 176 | 180 | 1.00 Reference | |||
rs17720428 | GG+GT | 87 | 67 | 0.1552 | 0.9314 | 1.3418 (0.8944–2.0129) |
TT | 120 | 124 | 1.00 Reference | |||
GG | 16 | 4 | 0.0101* | 0.0608 | 3.9162 (1.2854–11.9317) | |
TT+GT | 191 | 187 | 1.00 Reference |
aAbbreviations: SNP, single-nucleotide polymorphism; OR, odds ration; 95% CI, 95% confidence interval.
bp-values were calculated by χ2 test.
cBonferroni correction was applied to get the corrected p-value, which equals to p-value×6. Statistical significance
*, p-value <0.05
**, p-value <0.01
***, p-value <0.001.