Table 3.
Univariate and Multivariate Analysis of Overall Survival for the Primary Set
| Characteristics | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Age | ||||
| <50 | 1(Reference) | 1 | 1(Reference) | 1 |
| 50–60 | 1.11(0.86–1.44) | 0.410 | 1.26(0.96–1.64) | 0.091 |
| 60–70 | 1.13(0.88–1.47) | 0.333 | 1.19(0.91–1.55) | 0.204 |
| 70–80 | 1.14(0.87–1.50) | 0.342 | 1.28(0.96–1.71) | 0.088 |
| >80 | 1.07(0.77–1.47) | 0.677 | 1.14(0.82–1.59) | 0.425 |
| Race | ||||
| White | 1(Reference) | 1 | 1(Reference) | 1 |
| Black | 1.03(0.86–1.23) | 0.747 | 0.98(0.82–1.18) | 0.871 |
| Other✱✱ | 1.04(0.87–1.23) | 0.685 | 1.17(0.97–1.39) | 0.929 |
| Sex | ||||
| Female | 1(Reference) | 1 | 1(Reference) | 1 |
| Male | 1.32(1,17–1.41) | 0.038✱ | 1.21(1.01–1.43) | 0.036✱ |
| Edmonson-Steiner classification | ||||
| Unknown | 1(Reference) | 1 | 1(Reference) | 1 |
| I | 0.74(0.56–0.99) | 0.040✱ | 0.89(0.67–1.18) | 0.415 |
| II | 0.82(0.67–1.00) | 0.055 | 0.97(0.79–1.18) | 0.747 |
| III | 1.07(0.87–1.32) | 0.488 | 1.17(0.95–1.44) | 0.140 |
| IV | 1.22(0.65–2.29) | 0.529 | 1.82(0.95–3.50) | 0.069 |
| T stage | ||||
| T1 | 1(Reference) | 1 | 1(Reference) | 1 |
| T2 | 1.39(1.10–1.75) | 0.006✱ | 1.32(1.04–1.68) | 0.023✱ |
| T3 | 1.40(1.19–1.66) | <0.001✱ | 1.42(1.19–1.70) | <0.001✱ |
| T4 | 1.40(1.13–1.75) | 0.002✱ | 1.47(1.17–1.84) | <0.001✱ |
| N stage | ||||
| N0 | 1(Reference) | 1 | 1(Reference) | 1 |
| N1 | 1.24(1.06–1.46) | 0.006✱ | 1.07(0.90–1.26) | 0.437 |
| Bone metastasis | ||||
| None | 1(Reference) | 1 | 1(Reference) | 1 |
| Yes | 1.20(1.00–1.44) | 0.045✱ | 1.29(1.04–1.60) | 0.022✱ |
| Brain metastasis | ||||
| None | 1(Reference) | 1 | 1(Reference) | 1 |
| Yes | 1.20(0.75–1.91) | 0.455 | 1.15(0.70–1.87) | 0.580 |
| Intrahepatic metastasis | ||||
| None | 1(Reference) | 1 | 1(Reference) | 1 |
| Yes | 1.08(0.85–1.38) | 0.543 | 0.96(0.75–1.23) | 0.752 |
| AFP | ||||
| Unknown | 1(Reference) | 1 | 1(Reference) | 1 |
| Elevated | 0.99(0.82–1.22) | 0.969 | 1.00(0.81–1.25) | 0.965 |
| Normal | 0.73(0.55–0.97) | 0.027✱ | 0.75(0.56–0.83) | 0.032✱ |
| Insurance status | ||||
| Uninsured | 1(Reference) | 1 | 1(Reference) | 1 |
| Insured | 1.03(0.90–1.18) | 0.693 | 1.10(0.94–1.28) | 0.217 |
| Marital status | ||||
| Unmarried | 1(Reference) | 1 | 1(Reference) | 1 |
| Married | 0.86(0.75–0.99) | 0.036✱ | 0.94(0.81–1.10) | 0.449 |
| Treatment | ||||
| No surgery | 1(Reference) | 1 | 1(Reference) | 1 |
| Local tumor destruction | 0.29(0.16–0.53) | <0.001✱ | 0.32(0.17–0.59) | <0.001✱ |
| Hepatectomy | 0.36(0.20–0.66) | <0.001✱ | 0.34(0.18–0.63) | <0.001✱ |
| Radiation | ||||
| None | 1(Reference) | 1 | 1(Reference) | 1 |
| Yes | 0.80(0.65–0.98) | 0.032✱ | 0.67(0.53–0.86) | 0.001✱ |
| Chemotherapy | ||||
| None | 1(Reference) | 1 | 1(Reference) | 1 |
| Yes | 0.60(0.53–0.69) | <0.001✱ | 0.56(0.48–0.65) | <0.001✱ |
Notes: ✱Indicates significance of P<0.05. ✱✱Indicates American Indian/AK Native, Asian/Pacific Islander, and unknown.
Abbreviations: AFP, alpha fetoprotein; HR, hazard ratio; CI, confidence interval.