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. 2021 Mar 5;7(10):eabe1527. doi: 10.1126/sciadv.abe1527

Fig. 5. Lynx1 deletion leads to excess local inputs onto ACAVIS neurons resulting in imbalanced local and long-range inputs in adulthood.

Fig. 5

(A) Experimental design to examine monosynaptic inputs onto ACAVIS neurons in adult WT and Lynx1 KO. (B) Representative images of local inputs (green) from ACA and secondary motor cortex (MOs) onto ACAVIS projection neurons in white. Scale bars, 100 μm. (C) The number of inputs onto ACAVIS is higher from local ACA and MOs brain regions in adult Lynx1 KO mice compared to adult WT (t test, t10 = 2.356, *P = 0.0402, six mice each) and comparable to adolescent WT level shown as a shaded region (5), (D) but not from long-range distal brain regions (t test, t10 = 0.1515, P = 0.8826, six mice each), leading to (E) disrupted local/long-range balance with excess local connectivity (t test, t10 = 3.264, **P = 0.0085, six mice each) near an adolescent level shown as a shaded region.