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. 2021 Mar 5;7(10):eabe0207. doi: 10.1126/sciadv.abe0207

Fig. 3. eCS implants promote neurogenesis and plasticity 20 weeks after sTBI.

Fig. 3

(A) Representative tiled images of ipsilesional hemisphere (left coronal sections) coronal sections with merged DAPI (blue), DCX (red), and BrdU (green) staining of eCS rat brain tissue; scale bar, 1 mm. (B) Colocalization of DCX+ and BrdU+ cells with DAPI+ cells as a percentage of DAPI+ cells for each treatment; Kruskal-Wallis, treatment: P < 0.001. (C) Representative tiled images of ipsilesional hemisphere (left coronal sections) with merged DAPI (blue), Syn1 (red), and NeuN (green) staining of eCS rat brain tissue; scale bar, 1 mm. Inset shows magnified images of DAPI+ and NeuN+ cells (merged; left) and Syn1+ cells (right) from the region represented by the dashed white square; scale bar, 100 μm. (D) Colocalization of Syn+ cells with NeuN+ cells as percentage of NeuN+ cells for each treatment. Kruskal-Wallis, treatment: P < 0.001. Post hoc LSD Mann-Whitney U test, *P < 0.05, **P < 0.01, and ***P < 0.001. Graphs show means ± SEM.