Table 2.
Plasma Biomarker Concentrations in Survivors and Nonsurvivors at 28 Days in Derivati on and Internal Validation Sets
| Derivation Set, pg/mL | Internal Validation Set, pg/mL | |||||||
|---|---|---|---|---|---|---|---|---|
| Biomarkers | All (n = 113) | Survivors (n = 51) | Nonsurvivors (n = 62) | P a | All (n = 78) | Survivors (n = 42) | Nonsurvivors (n = 36) | P a |
| IL-6 | 252 (33–1980) | 41 (16–239) | 1938 (132–1980) | <.001 | 109 (36–1305) | 44 (21–110) | 948 (118–2080) | <.001 |
| IL-8 | 111 (11–479) | 14 (5–49) | 304 (78–1725) | <.001 | 41 (7–251) | 9 (3–41) | 181 (55–1729) | <.001 |
| G-CSF | 169 (54–4165) | 59 (32–209) | 1680 (117–11388) | <.001 | … | … | … | |
| IFN-γ | 1078 (350–3213) | 538 (188–1618) | 2027 (875–4780) | <.001 | … | … | … | |
| IL-1β | 3.6 (2–12) | 2 (2–7) | 7 (2–25) | <.001 | … | … | … | |
| TNF-ɑ | 27 (12–73) | 14 (6–37) | 50 (20–103) | <.001 | … | … | … | |
| IL-17A | 57 (14–132) | 18 (12–74) | 75 (37–163) | <.001 | … | … | … | |
| IL-10 | 23 (34–50) | 5 (2–28) | 34 (17–65) | <.001 | … | … | … |
Data are presented as median (IQR).
Abbreviations: G-CSF, granulocyte-colony stimulating factor; IFN-γ, interferon-γ; IL, interleukin; IQR, interquartile range; TNF-ɑ, tumor necrosis factor-ɑ.
a P values for Mann-Whitney U test of biomarker level between subjects alive and dead at 28 days.