Table 3.
Association of Biomarkers With 28-Day Mortality in the Derivation Set
| Unadjusted | Adjusteda | Modified SOFA-Adjustedb | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Biomarker (log10) | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P |
| IL-6 | 4.43 | 2.55–7.70 | <.001 | 4.59 | 2.58–8.17 | <.001 | 3.62 | 1.97–6.66 | <.001 |
| IL-8 | 4.09 | 2.40–6.97 | <.001 | 4.37 | 2.47–7.71 | <.001 | 3.44 | 1.87–6.32 | <.001 |
| G-CSF | 2.95 | 1.86–4.67 | <.001 | 3.13 | 1.93–5.06 | <.001 | 2.71 | 1.64–4.49 | <.001 |
| IFN-γ | 3.03 | 1.65–5.60 | <.001 | 2.93 | 1.58–5.41 | .001 | 2.29 | 1.20–4.31 | .01 |
| IL-1β | 4.14 | 1.94–8.81 | <.001 | 4.77 | 2.12–10.75 | <.001 | 3.65 | 1.57–8.47 | .003 |
| TNF-ɑ | 4.54 | 2.10–9.80 | <.001 | 4.45 | 2.02–9.79 | <.001 | 2.54 | 1.10–5.85 | .03 |
| IL-17A | 4.39 | 2.02–9.52 | <.001 | 4.79 | 2.09–10.93 | <.001 | 2.74 | 1.13–6.68 | .03 |
| IL-10 | 3.33 | 1.82–6.05 | <.001 | 3.34 | 1.81–6.18 | <.001 | 2.06 | 1.05–4.03 | .04 |
Abbreviations: CI, confidence interval; G-CSF, granulocyte-colony stimulating factor; IFN-γ, interferon-γ; IL, interleukin; OR, odds ratio; SOFA, Sequential Organ Failure Assessment; TNF-ɑ, tumor necrosis factor-ɑ.
aFor the adjusted model, P values were determined using logistic regression adjusted for age, sex, and Charlson Comorbidity Index.
b For the modified SOFA-adjusted model, P values were determined using logistic regression adjusted for age, sex, Charlson Comorbidity Index, and modified SOFA score.