Table 4.

Mortality Prediction Using Models of Clinical Variables With or Without IL-6 and IL-8 in the Derivation Set

Model and Variable	OR	95% CI	P
Clinical variables
Age	0.99	.95–1.04	.88
Female sex	2.47	1.01–6.04	.05
Charlson Comorbidity Index	1.12	.75–1.66	.55
Modified SOFA score	1.32	1.16–1.51	<.001
Clinical variables + IL-6a
Age	1.00	.95–1.06	.88
Female sex	2.89	1.07–7.95	.04
Charlson Comorbidity Index	1.06	.69–1.65	.78
Modified SOFA score	1.18	1.02–1.36	.02
IL-6	3.62	1.97–6.66	<.001
Clinical variables + IL-8b
Age	0.99	.94–1.05	.87
Female sex	2.65	.99–7.12	.05
Charlson Comorbidity Index	1.21	.77–1.91	.41
Modified SOFA	1.16	.99–1.35	.05
IL-8	3.44	1.87–6.32	<.001

Abbreviations: CI, confidence interval; IL, interleukin; OR, odds ratio; SOFA, Sequential Organ Failure Assessment.

^aModel containing clinical variables and log₁₀ IL-6 differed significantly by likelihood ratio test (P = 7.6 × 10⁻⁶) compared with the clinical variable model.

^bModel containing clinical variables and log₁₀ IL-8 differed significantly by likelihood ratio test (P = 1.1 × 10⁻⁵) compared with the clinical variable model.