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. Author manuscript; available in PMC: 2022 Feb 18.
Published in final edited form as: Mol Cell. 2021 Jan 29;81(4):649–658. doi: 10.1016/j.molcel.2021.01.012

Figure 1. DNA replication stress response mechanisms.

Figure 1.

Replication obstacles (represented by the red triangle) transiently stall fork progression. Replication obstacles can be “tolerated” by three distinct pathways to allow resumption of replication fork progression: translesion synthesis (left), template switching or fork reversal (middle), and repriming (right).