Figure 2.

(A) Representative T1-weighted axial images of rats dosed with PBS (left), with DEN and imaged 7 days after 4^th DEN dose (middle), and imaged one day after 4^th DEN dose (right). False color overlay represents subtraction image of pre-contrast image from the one minute post EP-2104R image. Peak liver signal enhancement (%ΔSI) at 1 min post injection of EP-2104R (B) and liver signal enhancement area under the curve (C) are significantly higher in the DEN treated rats than in PBS controls. * P<0.05, one way ANOVA with post hoc Tukey test.