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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Invest Radiol. 2020 Apr;55(4):209–216. doi: 10.1097/RLI.0000000000000631

Figure 3.

Figure 3.

Representative liver signal enhancement versus time post probe injection for EP-2014R (filled squares) and CLP (open circles) in rats imaged 7 days (A) or 1 day (D) post the last DEN dose. Peak (at 1 minute post injection) liver %ΔSI (B) and liver AUC (C) are not significantly different for EP-2104R and control probe CLP at 7 days post DEN. At 1 day post DEN, both peak liver (at 1 minute post injection) %ΔSI (E) and liver AUC (F) are significantly higher for EP-2104R indicating elevated fibrin levels during the inflammatory phase which results in increased relaxivity of EP-2104R and increased retention in liver tissue. * P<0.05, two tailed t-test.