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(A) ΔR1 of liver after administration of collagen-targeted EP-3533 measured 1 day or 7 days following the last DEN administration. EP-3533 reports on fibrosis and this data suggests no change in fibrotic burden after one week of withdrawal from DEN as expected. Peak EP-2104R liver signal enhancement (B) and EP-2104R liver signal enhancement AUC (C) are significantly decreased from 1 day post DEN to 7 days post DEN in these animals. * P<0.05, two tailed t-test.
