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Longitudinal scores for upper motor neuron burden scales for 53 patients with PLS. Solid lines indicate subject-specific intercepts and slopes and gray dots show individual scores A) UK UMN score B) MGH-UMNB scale and C) UPENN UMNS scale. All three scales increase more rapidly in the first 7.8 years, followed by flattening of scores afterwards. Note that many individuals in Panels A and B attain scores near the maximum for the UMNB scale.
